A study on evaluating lipid profile of patients with diabetes mellitus

Background: The diabetic patients are at increased risk to develop lipid abnormalities (hyperlipidemia). Diabetic patients who have lipid abnormalities are more prone to develop cardiovascular diseases. The aim of the current study was to estimate lipid profiles of patients with type-2 diabetes mellitus at Savar area, Dhaka, Bangladesh.Methods: This was a multidisciplinary study conducted between January to April, 2017. A total of 105 known cases of type-2 diabetic patients were investigated. Demographic characteristics and clinical data situation of the patients were taken by interview questionnaire. About 5 ml of fasting venous blood sample was collected from each subject for biochemical analysis. Data obtained were analyzed using Statistical Package of Social Sciences (SPSS-IBM) version 22.Results: Out of 105 patients, 64.8% patients were male and 35.2% were female. The mean±SD for age of patients was 47.67±5.9. The pattern of lipid abnormalities estimated was high serum triglycerides (TGs) in 58.1% patients, high serum total cholesterol (TC) in 61.9%, low high-density lipoprotein cholesterol (HDL-C) in 44.8%, high low-density lipoprotein (LDL-C) in 53.3%. Among all the variables only HDL levels was found significantly associated with age group (p=0.043). Study also revealed that, among all the variables only LDL-C level was found significantly associated with education (p=0.028) and TC level was associated with gender (p=0.003).Conclusions: Hyperlipidemia is a common complication of diabetes mellitus. Therefore maintaining good lipid profile can prevent development and progression of related complications among patient with diabetes mellitus.

Hyperuricaemia and its Relations with Serum Lipid Abnormalities in Untreated, Newly Diagnosed Adult Nigerian Hypertensive Patients.

Aims: To determine the prevalence of hyperuricaemia in adult Nigerians with untreated newly diagnosed hypertension and to evaluate its relations with serum lipid abnormalities. Study Design: Cross-sectional study. Place and Duration of Study: General Out-patient Department, Medical Out-patient Department and Emergency Room of the University of Ilorin Teaching Hospital, Ilorin, Nigeria between May 2007 and October 2007. Methodology: One hundred and fifty (150) untreated newly diagnosed hypertensive patients 18 years and above and one hundred and fifteen (115) age and sex-matched normotensive individuals were recruited into the study. Thorough clinical evaluation and laboratory investigations were done for both patients and controls including serum uric acid and serum lipid profile. Atherogenic ratio (Total cholesterol/Low density lipoprotein-cholesterol) was calculated for both patients and controls. Results: Of the one hundred and fifty newly diagnosed hypertensive patients, 52 (34.7%) were males and 98 (65.3%) females, with a range of 19-85 years and a mean age (±SD) of 50.412.3 years. Among the normotensive controls, 49 (42.6%) were males and 66 (57.4%) females with range of 23-80 years and a mean (±SD) of 50.712.7 yrs. Mean serum UA in hypertensive patients and normotensive controls was 0.40.1 mmol/l and 0.30.1 mmol/l respectively. Hyperuricaemia was found in 36.7% of hypertensive patients and 17.4% of normotensive controls (P<0.001). Serum UA was significantly higher in hypertensive patients than in normotensive controls (P<0.0001). Among hypertensive patients high TC and high LDL-c were the most prevalent types of serum lipid abnormalities. There was a significant positive correlation between serum UA and TG (r=0.21, P = 0.01). Conclusion: The study shows that hyperuricaemia and serum lipid abnormalities are prevalent among adult Nigerians with hypertension. There was a significant correlation between serum uric acid and serum triglyceride. This study recommends routine measurement of serum uric acid in both newly diagnosed hypertensive patients as well as those on antihypertensive drugs.

Research advances in relationship between microelements and metabolic syndrome in children / 中华临床营养杂志

The prevalence of the metabolic syndrome (MS) in children has increased over the last decade.Research shows that the microelements including zinc,copper,iron,chromium,and selenium are relevant with the development of childhood MS.This article summarizes the recent advances in the relationship between microele-ments and MS.

Modern pharmacotherapy of lipid abnormalities / 医学研究生学报

Lipid abnormality is a major risk factor of atherosclerosis and coronary heart disease.Pharmacological agents used to manage lipid abnormalities have been rapidly developed in recent years.Many new drugs have shown significant effects in the regulation of lipid abnormalities.Eight groups of drugs used to regulate lipid abnormalities were outlined in this paper,and the current recommendation for regulation of lipid abnormalities with some new drugs were discussed in details.

Blood pressure regulation of statins / 中国临床药理学与治疗学

Statins is first choice of hypercholesteroiemia. Recently, clinical investigations have shown that statins can correct blood pressure in hypertension patients accompanied with lipid abnormalities. This result can be observed not only in untreated patients but also in patients treated with antihypertensive drugs. But some researches did not support this result completely. To some extend, the mechanisms responsible for the hypotensive effect seem to be largely independent on the effect of statins on lipid profile, and may be related to the improvement of endothelial function and the regulation of angiotensin II receptors.